If you read Dune, by Frank Hurbert you know what a great book it was. Also if you dive a little deeper in the Dune universe you would also know about some games made about it. Some of them were succesfull. I think it would do well for SINS. But to make this clear, I DO NOT KNOW HOW TO MOD! Someone else would have to do it. I could help with research the strory and come up with ideas for the MOD.
What I would do for the MOD.
1. Guild Heighliners, you would need to pay for them so you could move around the map.
2. The noble houses, diffrent houses have diffrent advantages and distavages.
3. Spice, that would probally replace one of the resources, or at least be added to them, since this is pretty importent.
4. The emperor, you would need to stay in good terms with him or face the might of the Sardaukar!
5. Bene gesserit, I am not sure what they could do but they seem importent.
6. Dune, since the planet is the only one that has spice you would ether need to negotiate for it with the house that controls it, take the planet by force, or ask the emperor for it.
7. Be more sneaky, since in the novel the waring with houses was frowned upon so having a war with assians would be prefered..
8. Diffrent tech tree.
So what do you think, could this work?